Tablet Presentation

Each uncoated orally disintegrating tablet contains:
Ondansetron IP 8 mg

Ondansetron is the serotonin receptor antagonist. It selectively blocks 5HT3 receptors. It is mainly used to treat nausea and vomiting caused by cytotoxic drugs anti- cancerous agent.

Indications & Usage

• Mostly used in paediatric population for the treatment of post-radiotherapy induced nausea and vomiting.
• Treats nausea and vomiting induced during chemotherapy
• Cholestatic pruritis
• Uremic pruritis

Mechanism of Action

• It selectively blocks 5HT3 receptors located in the nerve terminal of the vagus in periphery and centrally in the chemotrigger zone of area postrema.
• It also blocks the serotonin released from the enterochromaffin cells located in the small intestine as these cells initiates vomiting reflex and causes nausea and vomiting

Pharmacokinetics

Absorption- It is absorbed orally
Protein Binding- It is 73% bound to serum proteins
Metabolism- It is metabolized in the liver
Excretion- It is excreted via urine and through feces

Side Effects

• Dizziness
• Drowsiness
• Tiredness
• Constipation
• Headache

Contraindications

Contraindicated in people with known hypersensitivity.

Precaution

Stop taking it if you have any one of the symptoms such as rashes, itching, hoarseness and swelling.